Speaker: Filip Morys (he/him), Montreal Neurological Institute and Hospital (grid.416102.0). Title: Obesity impairs cognitive feature via metabolic disorder and also cerebrovascular disease: an SEM analysis in 15,000 grownups from the UK Biobank. Host: Roozbeh Farhoodi. Backend host: Pavithra Rajeswaran. Information: https://neuromatch.io/abstract?submission_id=recC7Pg6LefJdujM2. Twitter: https://twitter.com/FilipKMorys. Provided throughout Neuromatch Conference 3.0, Oct 26-30, 2020. Below we make use of structural formula modelling in 15,000 individuals from the UK Biobank to identify the causal chain linking adiposity to cognitive disorder. We located that body mass index as well as waist-to-hip proportion were positively associated to higher plasma C-reactive protein, dyslipidemia, event of hypertension and also diabetes, all of which were in turn relevant to cerebrovascular condition as gauged by quantity of white issue hyperintensities on magnetic vibration imaging. White mater hyperintensities were linked with lower cortical thickness and volume and also greater subcortical volumes, which were connected with cognitive shortages.